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Chloroquine

From SNPedia

Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside of the intestines, rheumatoid arthritis, and lupus erythematosus.Wikipedia

The FDA-approved drug label for chloroquine (Aralen) states caution should be taken when administering treatment to G6PD deficient individuals due to the possibility of hemolytic anemia. Full details are available here.


PGx Table for Chloroquine (Aralen)
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Anti-malarial Infectious Disease Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).
gs307 Carrier G6PD Anti-malarial Infectious Disease Use with Caution You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking chloroquine; due to variable expression (i.e. in females, consider enzymatic testing if warranted.
gs308 G6PD-deficient G6PD Anti-malarial Infectious Disease Use with Caution You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking chloroquine; use this drug with caution.