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Crigler-Najjar syndrome

From SNPedia


Crigler-Najjar syndrome is a rare inherited condition that affects the metabolism of bilirubin, a breakdown product of red blood cells. Wikipedia Liver or hepatocyte transplantation may be necessary in Type I disease, which is much more severe than Type II. Gene therapy is being investigated for this condition.

Carriers of a single risk allele are usually not affected. SNPs associated with this syndrome (and often with Gilbert's syndrome and/or transient newborn jaundice) include