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Mafenide

From SNPedia

Mafenide (usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. Mafenide is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms.Wikipedia

The FDA-approved drug label [1] for mafenide states that fatal hemolytic anemia with disseminated intravascular coagulation has been reported following treatment with mafenide, possibly related to a G6PD-deficiency. However, no particular precaution, warning or test is discussed.

PGx Table for Mafenide (Sulfamylon)
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Anti-microbial Infectious Disease Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).
gs307 Carrier G6PD Anti-microbial Infectious Disease Use with Caution You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking mafenide.
gs308 G6PD-deficient G6PD Anti-microbial Infectious Disease Use with Caution You carry a G6PD mutation potentially linked to an unwanted side effect (hemolytic anemia) when taking mafenide; be aware of this possibility.