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Rasburicase

From SNPedia

Rasburicase, sold under trade names including Elitek, Fasturtec, and Rasuritek, is a medication that helps to clear uric acid from the blood.Wikipedia A pegylated form of rasburicase, pegloticase, is also FDA-approved for the treatment of refractory gout.

Both rasburicase and pegloticase carry FDA and EMA warnings indicating that they should not be used in patients with G6PD-deficiency.


PGx Table for Rasburicase
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Leukemia; Gout Oncology; Rheumatology Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia and methemoglobinemia).
gs307 Carrier G6PD Leukemia; Gout Oncology; Rheumatology Use with Caution You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia and methemoglobinemia) when taking rasburicase; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable.
gs308 G6PD-deficient G6PD Leukemia; Gout Oncology; Rheumatology Avoid Use You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia and methemoglobinemia) when taking rasburicase; rasburicaseshould not be prescribed for you according to the FDA.